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fazal.wahab@fbse.paf-iast.edu.pk
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Dr. Fazal Wahab

Associate Professor

Biography

Dr. Fazal Wahab is Associate Professor and Chairman Department of Biomedical Sciences, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Pakistan. He has extensive research work experience in field of germline stem cell biology, epigenetics regulation of spermatogenesis, molecular and cellular reproductive endocrinology. He has published 35 publications in internationally well reputed impact factor journals. His research work is cited >600 times by peers all round the world. Importantly, he was involved in uncovering the vital role of kisspeptin signaling in the metabolic regulation of reproduction.  

Education

  • Ph.D. in Molecular Endocrinology, Quaid-i-Azam University, Islamabad, Pakistan and Harvard University, USA, 2005-2011
  • M.Phil. in Molecular Endocrinology, Quaid-i-Azam University, Islamabad, Pakistan and Harvard University, USA,2006

Publications

  • Wahab F*, Drummer C, Mätz-Rensing K, Fuchs E, Behr R (2020). Irisin is expressed by undifferentiated spermatogonia and modulates gene expression in organotypic primate testis cultures in vitro. Molecular and Cellular Endocrinology, 504:110670. doi: 10.1016/j.mce.2019.110670.
  • Wahab F*, Khan IU, Polo IR, Zubair H, Drummer C, Shahab M, Behr R (2019). Irisin in the primate hypothalamus and its effect on GnRH in vitro. Journal of Endocrinology pii: 241(3):175-187. doi: 10.1530/JOE-18-0574
  • Zheng W, Nazish J, Wahab F, Khan R, Jiang X, Shi Q (2019). DDB1 Regulates Sertoli Cell Proliferation and Testis Cord Remodeling by TGFβ Pathway. Genes (Basel). 2019 Nov 26;10(12). pii: E974. doi: 10.3390/genes10120974
  • Xie Y, Khan R, Wahab F, Hussain HMJ, Ali A, Ma H, Jiang H, Xu J, Zaman Q, Khan M, Jiang X, Shi Q. The testis-specifically expressed Dpep3 is not essential for male fertility in mice. Gene. 2019 Aug 30;711:143925. doi: 10.1016/j.gene.2019.06.015
  • Hussain HMJ, Murtaza G, Jiang X, Khan R, Khan M, Kakakhel MBS, Khan T, Wahab F, Zhang H, Zhang Y, Khan MB, Ahmed P, Ma H, Xu Z (2019). Whole exome sequencing revealed a novel nonsense variant in GNRHR gene causing normosmic hypogonadotropic hypogonadism in a Pakistani family. Hormone Research in Paediatrics 4;91(1):1-8
  • Wahab F, Atika B, Ullah F, Shahab M, Behr R. Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway. Frontier Endocrinology 9:123. doi: 10.3389/fendo.2018.00123

Awards & Prizes

  • PIFI postdoctoral Award from Chinese Academy of Sciences ,2018
  • Travel Grant from European Union PRIMTRAIN cost Action for a workshop and a school in KU Leuven, Belgium (April) and University of Oxford, UK (December) ,2017
  • Best Abstract Award and Young Investigator Travel Grant from the International Neuroendocrine Federation (INF) for presentation in a Congress of INF, Rouen, France,2010
  • Best Research Abstract and Young Investigator Travel Grant (July 2009) provided by the International Union of Physiological Sciences for poster presentation in International Union of Physiological Sciences, Kyoto, Japan ,2009
  • Young Neuroendocrinologist Travel Award (August 2009) was awarded by INF to attend 2nd School of Neuroendocrinology in Kitakyushu, Japan,2009
  • The Best Research Abstract Award and Travel Grant (October 2008) was awarded by the International Neuroendocrine Federation in Cordoba, Spain,2008
  • Ph.D. Student Travel Grant for an oral presentation (October 2008) was granted by HEC for presentation at the European Neuroendocrine Federation meeting in Antalya, Turkey,2008
  • Dr. Atique Memorial Shield for a best poster presentation (November 2008) was awarded by the South Asian Association of Physiologists and Pakistan Physiological Society for best poster presentation,2008

Projects

  • Role of MOF and irisin signaling in hypothalamic regulation of kisspeptin and GnRH release. This project is funding by Humboldt foundation
  • Role of Mof gene in regulation of Spermatogonial Stem Cells (SSCs) Differentiation. This project was funded by the Chinese Academy of Sciences.
  • The role of irisin signaling pathways in regulation of GnRH secretion. This project was funded (06/2016 to 03/2018) by Humboldt foundation of Germany.
  • Rabconnectin-2, irisin, kisspeptin and GnIH involvement at the onset of primate puberty. This project was also funded (11/2014 to 10/2016) by Humboldt foundation of Germany.