Dr. Saif Ullah

Dr. Saif Ullah has done Pharm-D, and M.Phil in Pharmaceutical Chemistry from Bahauddin Zakariya University Multan, Pakistan. In August 2023, He has completed the Ph.D. in Pharmaceutical Chemistry with thesis title “Design and Synthesis of Sulphonate Derivatives as Potent Inhibitors of ENPP1” from Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan. In the Ph.D. work, He has designed, optimized, synthesized and characterized the organic compounds. He has evaluated the synthesized organic compounds on enzyme inhibitory activity, insulin secretagogues effect on freshly isolated islets of Langerhans’s from Balb/c mice, glucose tolerance, blood insulin level test in diabetic rat models, cancer cell lines and normal cell lines viability assay and molecular docking study.  

1. Haseen Ahmad, Saif Ullah, Nabiha Abdullah, Abid Hussain Khan, Farman Ullah, Imtiaz A. Khan, Julie Pelletier et al. “Synthesis of 1, 3, 4-Oxadiazole Derivatives via Transition Metal Catalyzed Cross-Coupling and their Biological Evaluation as Selective Inhibitors of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase)-2,-3 and-8 Inhibitors.” Journal of Molecular Structure (2025): 142731. (I.F = 3.8, X) https://doi.org/10.1016/j.molstruc.2025.142731
2. Saif Ullah, Kiran Hamid, Amna Batool, Saira Afzal, Julie Pelletier, Jean Sévigny, Abdul Rehman Khan, and Peter Langer. Synthesis of new sulphonate derivatives containing adamantane and 4-chlorophenyl moieties as nucleotide pyrophosphatase/phosphodiesterase-1 and-3 inhibitors. Journal of Molecular Structure, 1274 (2023), 134494 (I.F = 3.84, X) https://doi.org/10.1016/j.molstruc.2022.134494
3. Saif Ullah (Co-1^st author), Saquib Jalil, Seyed-Omar Zaraei, Rawan M. Sbenati, Afnan I. Shahin, Bilal O. AlKubaisi, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, and M.I. El-Gamal” Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX.” Medicinal Chemistry Research (2023), 32, no. 5: 869-883. (I.F = 3.1, W) https://link.springer.com/article/10.1007/s00044-023-03043-9

4. Saif Ullah, Julie Pelletier, Jean Sévigny and Jamshed Iqbal. “Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors”. ACS Omega. 30 (2022): 26905-26918. (F = 4.32, W) https://pubs.acs.org/doi/full/10.1021/acsomega.2c03473
5. Saif Ullah, Mohammed I. El-Gamal, Randa El-Gamal, Julie Pelletier, Jean Sévigny, Mahmoud K. Shehata, Hanan S. Anbar, and Jamshed Iqbal. “Synthesis, biological evaluation, and docking studies of novel pyrrolo [2, 3-b] pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents.” European Journal of Medicinal Chemistry217 (2021): 113339. (F = 6.78, W) https://doi.org/10.1016/j.ejmech.2021.113339

• HEC Indigenous Ph.D. Scholar: It was awarded by the Higher Education Commission (HEC) of Pakistan based on the high scores in the test taken by HEC for HEC Indigenous Ph.D. scholarship in Punjab